The invention describes a compound pyridinopyridine (I) or a new derivative of an acceptable pharmaceutical salt； (I) R1 is a halogen, cyanogen or C1-C3 tar, which can be replaced by halogen； R2 is a C1-C6 tar, which can be replaced by C1-C6 tar once or more, alqueniloc2-c6, hydroxy, N. N-di-let C1-C6, n-mono-let C1-C6, o-rg, RG, phenyl,OR BY ALCOXILOC1-C6 WHERE SUCH ALCOXILO AGAIN CAN BE OPTIONALLY REPLACED BY C1-C6, N, N-DI-ALKYLAMINO C1-C6, RG OR PHENYL； CYCLOALKYL C3-C6 OPTIONALLY REPLACED BY C1-C6 ALKYL, N, N-DI-C1-C6 ALKYLAMINE OR C1-C6-ALKYL C1-C6 ALKYL, AND / OR TWO OF SUCH OPTIONAL SUBSTITUTES TOGETHER WITH THE ATOMS TO WHICH THEY ARE ONE MAY FORM A NULL OR SPYROCYCLED SATURATED HETERO-CYCLIC RING OF 4-6 MEMBERS INCLUDING 1 - 2 0 ATOMS； PHENYL OPTIONALLY REPLACED BY ALCOXYLOC1-C6； A HETEROARYL RING OF 5 - 6 MEMBERS THAT HAS 1 TO 3 SELECTED N AND O HETEROATOMS,The ring can be replaced by C1-C6 tar, which can be replaced by amino group or hydroxyl group； RG； or N, n-di-rental carbon C1-C6； R is phenyl, which can be replaced by RA or 2-piridilo twice or more independently, and Rb once or more independently. (3) Pyridilo is replaced once or more by RC alone, or four times by RD alone. The latter usually interacts with Maltese conservation and / or self-protection activities, especially may hinder such activities. The invention further expounds the synthesis of these new pyridine pyridine derivatives,Use as a drug, especially through interactions between protection and / or self activities1 in MaltaLA PRESENTE INVENCIÓN DESCRIBE NUEVOS DERIVADOS DE LA PIRAZOLO-PIRIMIDINA DE LA FÓRMULA (I) O UNA SAL FARMACÉUTICAMENTE ACEPTABLE DEL MISMO； (I) EN LA QUE, R1 ES HALÓGENO, CIANO, O ALQUILO C1-C3 OPCIONALMENTE SUSTITUIDO POR HALÓGENO； R2 ES ALQUILO C1-C6 OPCIONALMENTE SUSTITUIDO UNA O MÁS VECES POR ALQUILO C1-C6, ALQUENILOC2-C 6, HIDROXILO, N,N-DI-ALQUILAMINO C1-C6, N-MONO-ALQUILAMINO C1-C6, O-RG, RG, FENILO , O POR ALCOXILOC1-C6 EN DONDE DICHO ALCOXILO DE NUEVO PUEDE
