PHARMACEUTICAL COMPOSITION CONTAINING A 1,2-DITHYOLTHIONE DERIVATIVE FOR PREVENTION OR TREATMENT OF A DISEASE DUE TO AN EXTENDED EXPRESSION OF LXR-ALPHA
КИМ Сан Гон (KR),КИ Сун Хван (KR),ХВАН Сон Хван (KR)
申请号：
RU2011108359/15
公开号：
RU2011108359A
申请日:
2009.07.30
申请国别(地区):
RU
年份:
2012
代理人:
摘要：
1. A pharmaceutical composition for the prevention and treatment of diseases caused by increased expression or increased activity of the hepatic X receptor (LXRα), containing, as an effective component, a compound of formula 1 below, a pharmaceutically acceptable salt, solvate, hydrate or prodrug thereof:! Formula 1 ! ! where X is carbon or nitrogen, Q is sulfur, oxygen, or —S = O and R1 and R2 are each independently selected from the group consisting of hydrogen atom, C1-7 alkyl, C3-7 cycloalkyl, C1-7 haloalkyl , C1-7-alkoxy, C3-7-cycloalkoxy, C1-7-alkylthio, C3-7-cycloalkylthio, C1-7-alkenyl, C1-7-alkynyl, C1-7-alkylsulfonyl, C1-7-alkylaminocarbonyl, HO -C1-7-alkyl, HS-C1-7-alkyl, hydroxy, thiol, halogen, carboxyl, nitro, cyano, C1-7-alkylcarbonyl, C1-7-alkoxycarbonyl, C1-7-alkylcarbonyloxy, C1-4-alkylcarbonyl C1-4alkyl, C1-4alkoxy-C1-4alkyl, C1-4alkylthio-C1-4alkyl, amino, C1-7alkylamino, C1-7 -alkylcarbonylamino, C1-4-alkoxy-C1-4-alkylamino, C1-4-alkylthio-C1-4-alkylamino, C1-4-alkylsulfonamino, phenyl, heteroaryl, phenyl-C1-4-alkyl, heteroaryl-C1-4 -alkyl, phenyl-C1-4-alkoxy-C1-4-alkyl, phenyl-C1-4-alkylthio-C1-4-alkyl, phenoxy-C1-4-alkyl, phenylthio-C1-4-alkyl, phenylcarbonylamino, phenoxy C1-4-alkylcarbonylamino, phenyl-C1-4-alkoxy-C1-4-alkylcarbonylamino, heteroaryloxy-C1-4-alkyl, heteroarylthio-C1-4-alkyl and heteroaryl-C1-4-alkylthio-C1-4-alkyl wherein heteroaryl refers to a 5- or 6-membered cyclic compound containing at least one heteroatom selected one from the group consisting of nitrogen, sulfur and oxygen； phenyl and heteroaryl can be substituted or unsubstituted and an available substituent can be selected from the group consisting of halogen, C1-7 alkyl, C1-7 alkoxy, C1-7 haloalk1. Фармацевтическая композиция для предотвращения и лечения заболеваний, обусловленных повышенной экспрессией или повышенной активностью печеночного Х рецептора (LXRα), содержащая в качестве эффективного компонента соединение формулы 1 ниже, его фармацевтически приемлемую со
