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LIPIDATED PEPTIDES FOR LOWERING BLOOD GLUCOSE
专利权人:
发明人:
LENKA MALETINSKA,Blanka Zelezna,Jaroslav Kunes,Veronika Prazienkova
申请号:
US15138631
公开号:
US20160228563A1
申请日:
2016.04.26
申请国别(地区):
US
年份:
2016
代理人:
摘要:
Lipidated analogs of prolactin-releasing peptides (PrRP) and their use in controlling and lowering blood glucose in mammals is disclosed. Useful compounds included lipidated analogs of PrRP20 and PrRP31. Pharmacological effects are demonstrated both in vitro and in vivo. Peripheral administration of the lipidated peptides towers blood glucose levels. These treatments are applicable for treating impaired glucose tolerance (IGT), and glucose intolerance condition. The disclosed compounds have application in treating medical conditions including diabetes, pre-diabetes, eating disorders, and obesity.
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