FYZIOLOGICKY USTAV AKADEMIE VED CESKE REPUBLIKY V V I
发明人:
申请号：
EP15723290.1
公开号：
EP3094643B1
申请日:
2015.01.15
申请国别(地区):
EP
年份:
2018
代理人:
摘要：
Lipidated analogs of prolactin-releasing peptides (PrRP) and their use in controlling and lowering blood glucose in mammals is disclosed. Useful compounds included lipidated analogs of PrRP20 and PrRP31. Pharmacological effects are demonstrated both in vitro and in vivo. Peripheral administration of the lipidated peptides towers blood glucose levels. These treatments are applicable for treating impaired glucose tolerance (IGT), and glucose intolerance condition. The disclosed compounds have application in treating medical conditions including diabetes, pre-diabetes, eating disorders, and obesity.
