David A. Stein,Qing Ge,Jianzhu Chen,Patrick L. Iversen,Hong M. Moulton
申请号：
US11259434
公开号：
US08357664B2
申请日:
2005.10.25
申请国别(地区):
US
年份:
2013
代理人:
摘要：
The invention provides antisense antiviral compounds and methods of their use and production in inhibition of growth of viruses of the Orthomyxoviridae family and in the treatment of a viral infection. The compounds are particularly useful in the treatment of influenza virus infection in a mammal. The antisense antiviral compounds are substantially uncharged morpholino oligonucleotides having 1) a nuclease resistant backbone, 2) 12-40 nucleotide bases, and 3) a targeting sequence of at least 12 bases in length that hybridizes to a target region selected from the following: a) the 5′ or 3′ terminal 25 bases of the negative sense viral RNA segment of Influenzavirus A, Influenzavirus B and Influenzavirus C b) the terminal 25 bases of the 3′ terminus of the positive sense cRNA and and c) the 50 bases surrounding the AUG start codon of an influenza viral mRNA.
