Sina Bavari;David A. Stein;Patrick L. Iversen;Dwight D. Weller
发明人:
David A. Stein,Patrick L. Iversen,Sina Bavari,Dwight D. Weller
申请号：
US12402464
公开号：
US08168604B2
申请日:
2009.03.11
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The invention provides antisense antiviral compounds and methods of their use and production in inhibition of growth of viruses of the Filoviridae family, and in the treatment of a viral infection. The compounds and methods relate to the treatment of viral infections in mammals including primates by Ebola and Marburg viruses. The antisense antiviral compounds are morpholino oligonucleotides having: a) a nuclease resistant backbone, b) 15-40 nucleotide bases, and c) a targeting sequence of at least 15 bases in length that hybridizes to a target region selected from the following: i) the Ebola virus AUG start site region of VP24； ii) the Ebola virus AUG start site region of VP35； iii) the Marburg virus AUG start site region of VP24； or iv) the Marburg virus AUG start site region of NP.
