AVI BIOPHARMA, INC.;GOVERNMENT OF THE UNITED STATES, AS REPRESENTED BY THE SECRETARY OF THE ARMY
发明人:
STEIN, DAVID A.,IVERSEN, PATRICK L.,BAVARI, SINA
申请号：
CA2584873
公开号：
CA2584873C
申请日:
2005.11.01
申请国别(地区):
CA
年份:
2017
代理人:
摘要：
The invention provides antisense antiviral compounds and methods of their useand production in inhibition of growth of viruses of the Filoviridae family,and in the treatment of a viral infection. The compounds and methods relate tothe treatment of viral infections in mammals including primates by Ebola andMarburg viruses. The antisense antiviral compounds are substantially unchargedmorpholino oligonucleotides having: a) a nuclease resistant backbone, b) 15-40nucleotide bases, and c) a targeting sequence of at least 15 bases in lengththat hybridizes to a target region selected from the following: i) the AUGstart site region of VP35, as exemplified by antisense compounds SEQ ID NO: 21-26, ii) the AUG start site region of VP24, as exemplified by antisensecompound SEQ ID NO:34, iii) the region 85 to 65 base pairs upstream of the AUGstart site of VP24, as exemplified by SEQ ID NO:39, iv) the AUG start siteregion of polymerase L, as exemplified by antisense compound SEQ ID NO: 17,and v) combinations of (i), (ii), (iii), and/or (iv).
