抗體藥物結合物农业专利-农业学术服务平台

发明人:: ABRAMS, TINYA,阿伯翰斯　亭亚,阿伯翰斯　亭亞,COHEN, STEVEN,可汗　史蒂芬,DAMIANO, JASON,达米安诺　杰生,達米安諾　傑生,DURR, CLEMENS,杜尔　克莱蒙斯,杜爾　克萊蒙斯,HUBER, THOMAS,哈柏　汤玛士,哈柏　湯瑪士,MENEZES, DANIEL,密那兹　丹尼尔,密那茲　丹尼爾,MILLER, KATHY,米勒　凯西,米,阿伯翰斯亭亚,阿伯翰斯亭亞,可汗史蒂芬,达米安诺杰生,達米安諾傑生,杜尔克莱蒙斯,杜爾克萊蒙斯,哈柏汤玛士,哈柏湯瑪士,密那兹丹尼尔,密那茲丹尼爾,米勒凯西

摘要：: This application discloses anti-P-cadherin antibodies, antigen binding fragments thereof, and antibody drug conjugates of said antibodies or antigen binding fragments. The invention also relates to methods of treating cancer using the antibodies, antigen binding fragments, and antibody drug conjugates. Also disclosed herein are methods of making the antibodies, antigen binding fragments, and antibody drug conjugates, and methods of using the antibodies and antigen binding fragments as diagnostic reagents.本申請案揭示抗P-鈣黏蛋白抗體、其抗原結合片段及該等抗體或抗原結合片段之抗體藥物結合物。本發明亦關於使用該等抗體、抗原結合片段及抗體藥物結合物治療癌症之方法。本文亦揭示製備該等抗體、抗原結合片段及抗體藥物結合物之方法，及使用該等抗體及抗原結合片段作為診斷試劑之方法。