This application discloses anti-CCR7 antibodies, antigen binding fragments thereof, and antibody drug conjugates of said antibodies or antigen binding fragments. The invention also relates to methods of treating or preventing cancer using the antibodies, antigen binding fragments, and antibody drug conjugates. Also disclosed herein are methods of making the antibodies, antigen binding fragments, and antibody drug conjugates, and methods of using the antibodies and antigen binding fragments as diagnostic reagents.本申請案揭示抗CCR7抗體、其抗原結合片段及該等抗體或抗原結合片段之抗體藥物結合物。本發明亦係關於使用抗體、抗原結合片段及抗體藥物結合物治療或預防癌症之方法。本文亦揭示製備抗體、抗原結合片段及抗體藥物結合物之方法,及使用抗體及抗原結合片段作為診斷試劑之方法。