LADNER, ROBERT CHARLES,LEY, ARTHUR C.,SATO, AARON K.,STOCHL, MARK
申请号:
CA2536873
公开号:
CA2536873C
申请日:
2004.08.30
申请国别(地区):
CA
年份:
2019
代理人:
摘要:
Disclosed are compounds that comprise: (i) a Kunitz domain polypeptide thatcomprises a Kunitz domain that binds to and inhibits a protease; and (ii) aplurality of polyethylene glycol moieties attached to the Kunitz domainpolypeptide. Each accessible primary amine of the Kunitz domain polypeptidecan be attached to one of the moieties. Also disclosed are related methods.