LADNER, ROBERT, CHARLES,LEY, ARTHUR, C.,SATO, AARON, K.,STOCHL, MARK
申请号:
DK04786615
公开号:
DK1663281T3
申请日:
2004.08.30
申请国别(地区):
DK
年份:
2014
代理人:
摘要:
Disclosed are compounds that comprise: (i) a Kunitz domain polypeptide that comprises a Kunitz domain that binds to and inhibits a protease; and (ii) a plurality of polyethylene glycol moieties attached to the Kunitz domain polypeptide. Each accessible primary amine of the Kunitz domain polypeptide can be attached to one of the moieties. Also disclosed are related methods.