Aaron K. Sato;Arthur C. Ley;Robert C. Ladner;Mark Stochl
发明人:
Arthur C. Ley,Aaron K. Sato,Robert C. Ladner,Mark Stochl
申请号：
US13463378
公开号：
US20120322744A1
申请日:
2012.05.03
申请国别(地区):
US
年份:
2012
代理人:
摘要：
Disclosed are compounds that comprise: (i) a Kunitz domain polypeptide that comprises a Kunitz domain that binds to and inhibits a protease； and (ii) a plurality of polyethylene glycol moieties attached to the Kunitz domain polypeptide. Each accessible primary amine of the Kunitz domain polypeptide can be attached to one of the moieties. Also disclosed are related methods.
