Compositions comprising an effective amount of mesoporous silica nanoparticles (MSNs) for use in prevention and/or treatment of steatorrhea in a subject in need thereof are disclosed. Also disclosed are compositions for use in exposing a liquid lipid to MSNs and causing the liquid lipid to gel and/or solidify, or compositions for use in exposing a liquid dietary lipid inside intestines of a subject to the MSNs and causing the liquid dietary lipid to gel and/or solidify inside the intestines of the subject, or compositions for use in reducing intestinal absorption of the liquid dietary lipid.
