VAN DEN BRINK, JOHANNES MAARTEN,LUND, MARTIN,JAECKEL, CHRISTIAN
申请号：
ARP170101352
公开号：
AR108527A1
申请日:
2017.05.19
申请国别(地区):
AR
年份:
2018
代理人:
摘要：
Claim 1: a single cosmetic polypeptide variant, including a change of one or more postures, rather than a cosmetic active parent polypeptide, in which substitution is included, 1. Remove or place on the position of at least one amino acid, equivalent to any of the following positions: s164, D59, v309, S132, n249, l166, n249, Q56, m157, m256, r242, i96, h76, S273, g251, Y11, l166, K19, y21, S74, y243, n249, S73, q280, f282, l295, n252, r254, G70, V136, l222, k231,N291, in which: (1) the amino acid position of the parent polypeptide is determined by the pairing of the parent polypeptide with seq-2 and (2) multiple peptides: the parent polypeptide and seq-2 mature polypeptide (camel venom) have at least 80% sequence characteristics；In this case, individual cosmetic peptide substitutes showed a higher specific coagulation activity and / or C / P ratio than their parents' corresponding peptides. Claim 7: a method of producing a separate chemotherapeutic peptide substitute according to any one of claims 1 to 6, including (a) a step of changing one or more positions of a parent peptide, including substitution in such a change, Remove or insert at least one corresponding amino acid position at any of the following positions: Y11, s164, l253, D59, v309, S132, n249, l166,N249, Q56, m157, m256, r242, i96, h76, s164, S73, g251, Y11, l166, K19, y21, S74, y243, n249, S73, q280, f282, l295, n252, r254, G70, V136, l222, k231, n291； (b) production and separation of modified polypeptide (a),In (I), the amino acid status of the parent peptide was determined by the combination of the parent peptide and the peptide in SEQ ID 2 (camel cosmetics)；Y (II): the parent's polypeptide has at least 80% of the sequence characteristics, with mature SEQ ID 3 (chemotherapy cow) polypeptide and / or at least 80% of the sequence characteristics, with mature SEQ ID 2 (chemotherapy camel) polypeptide. 11. Claim 11: a method for producing food for human or animal consumption, including the separation of
