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LIQUID PREPARATIONS OF AMINES AND ORGANIC ACIDS STABILIZED BY SALTS
专利权人:
ТАКЕДА ФАРМАСЬЮТИКАЛ КОМПАНИ ЛИМИТЕД (JP)
发明人:
ИКЕДА Мегуми (JP),ХОРИУТИ Сохеи (JP),САТО Томоми (JP),НАКАИ Синитиро (JP),КИЙОСИМА Кенитиро (JP)
申请号:
RU2015102333
公开号:
RU2015102333A
申请日:
2013.06.26
申请国别(地区):
RU
年份:
2016
代理人:
摘要:
1. A liquid preparation containing a pharmaceutically active ingredient having a primary or secondary amino group, where the amino group is not part of the amido group, an organic acid and a salt that essentially does not contain the reaction product of the pharmaceutically active ingredient and an organic acid. A liquid preparation according to claim 1, which is a solution for injection. A liquid preparation according to claim 1, containing not more than 1.8 times the amount in% of the reaction product of the pharmaceutically active ingredient and the organic acid after aging at 70 ° C for 1 week from the amount to aging. A liquid preparation according to claim 1, containing not more than 1.3 times the amount in% of the reaction product of the pharmaceutically active ingredient and the organic acid after aging at 60 ° C for 1 week from the amount to aging. A liquid preparation according to claim 1, wherein the pharmaceutically active ingredient is a non-peptide compound. The liquid preparation according to claim 5, wherein the non-peptide compound is a compound represented by the formula (I) RX-NH-R (I), in which R represents an organic residue, R represents a hydrogen atom or an organic residue, and X represents a bond or spacer group having 1-20 atoms in the main chain, provided that -NH- in the formula is not part of the amide group. The liquid preparation according to claim 5, wherein the non-peptide compound is a compound represented by formula (II) in which X and Y are the same or different and each represents a bond or spacer group having 1-20 atoms in the main chain, R represents a hydrogen atom or optionally substituted hydrocarbon group, R 1 represents optionally1. Жидкий препарат, содержащий фармацевтически активный ингредиент, имеющий первичную или вторичную аминогруппу, где аминогруппа не является частью амидогруппы, органическую кислоту и соль, который по существу не содержит продукт реакции фармацевтически активного ингредиента и органической кислоты
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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