(I) A compound of formula (I) or a pharmaceutically acceptable salt or prodrug thereof, for use in therapy is provided, wherein X is CR9R10, O, S, S=O or SO2； X1 is CR1 or N； X2 is CR2 or N； X3 is CR3 or N； the or each Z is independently CR11R12 or NR11； n is 1 or 2； Q is C=O, S=O, SO2, C=S or CR4R5； L is optionally substituted C1-C6alkyl, C1-C3polyfluoroalkyl, optionally substituted C3-C6cycloalkyl, optionally substituted C2-C6alkenyl, optionally substituted C2-C6alkynyl, C=O, S=O, SO2, -CH2C(O)-, -CH2CONH- or -CONH-； Y is an optionally substituted C1-C6alkyl, C1-C3polyfluoroalkyl, an optionally substituted C2-C6alkenyl, an optionally substituted C2-C6alkynyl, an optionally substituted C3-C6cycloalkyl, an optionally substituted mono or bicyclic 3 to 8 membered heterocycle； R6 is mono or bicyclic optionally substituted C5-C10aryl, mono or bicyclic optionally substituted 5 to 10 membered heteroaryl, optionally substituted C3-C6cycloalkyl or an optionally substituted mono or bicyclic 3 to 8 membered heterocycle； R8 is mono or bicyclic optionally substituted C5-C10 aryl, mono or bicyclic optionally substituted 5 to 10 membered heteroaryl, optionally substituted mono or bicyclic C3-C6cycloalkyl or an optionally substituted mono or bicyclic 3 to 8 membered heterocycle； R1, R2, R3, R4, R5, R7, R9, R10, R11 and R12 are each independently substituents as herein defined, with the proviso that the compound of formula (I) is not a compound as herein defined. The compounds of formula (I) are for use in modulating the stimulator of interferon genes (STING) protein, preferably for the treatment of disease such as cancer and microbial infections. Per se compounds of formula (I) as herein defined are also provided.
