ARMITAGE, IAN G.,LANGSTON, MARIANNE,COOPER, MARTIN IAN,CHOPRA, REENU
申请号：
PE2016001604
公开号：
PE20161222A1
申请日:
2010.05.13
申请国别(地区):
PE
年份:
2016
代理人:
摘要：
It refers to a formula of XRPD (1s, 2S, 4R) - 4 - {4 - [(1s) - 2, 3-dihydro-1h-inden-1-ilamino] - 7h-pirrolo [2, 3-d] pirimidin-7-il} - 2-hydrocyclopentil) formic acid with a 2 (theta) eel mouth, which is characterized by an XRPD guardian with a 2 (theta) eel mouth.9.6%13.6%14.5,14.8 degrees16.5,1700,17.3.1800,Nineteen point oneTwenty point oneTwenty-one point one21.7 degrees23.7 + 0.2 degrees He also mentioned a method of access and a formula for a drug. This crystal is an active E1 enzyme inhibitor and is useful in cancer treatment.Se refiere a un cristal de clorhidrato ((1S,2S,4R)-4-{4-[(1S)-2,3-dihidro-1H-inden-1-ilamino]-7H-pirrolo[2,3-D]pirimidin-7-il}-2-hidroxiciclopentil)metilsulfamato de formula I caracterizado por un patron XRPD que tiene picos de angulos 2(theta): 7.3º, 9.6º, 13.6º, 14.5º, 14.8º, 16.5º, 17.0º, 17.3º, 18.0º, 19.1º, 20.1º, 21.1º, 21.7º, 23.7º ± 0.2 grados. Tambien se refiere a un metodo de obtencion y a una formulacion farmaceutica. Dicho cristal es un inhibidor de enzima activante de E1, siendo util en el tratamiento del cancer
