ARMITAGE, IAN G.,LANGSTON, MARIANNE,COOPER, MARTIN IAN,CHOPRA, REENU
申请号：
PE0016042016
公开号：
PE12222016A1
申请日:
2010.05.13
申请国别(地区):
PE
年份:
2016
代理人:
摘要：
It refers to a Crystal hydrochloride ((1S, 2S, 4R) - 4 - (4 - [(1S) - 2,3 dihydro - 1 - 1 - ilamino inden -] - 7h pyrrolo [2,3-d] pyrimidine 7 - il} - 2 - hidroxiciclopentil) characterized by metilsulfamato formula I a pattern that has 2 Peaks XRPD Angle (Theta): 7.3\u00ba, 9.6\u00ba, 13.6\u00ba, 14.5\u00ba, 14.8\u00ba, 16.5\u00ba, 17.0\u00ba, 17.3\u00ba, 18.0\u00ba, 19.1\u00ba, 20.1\u00ba, 21.1\u00ba, 21.7\u00ba, 23.7\u00ba + - 0.2 degrees.It also relates to a production method and a Pharmaceutical formulation. The Glass is an inhibitor of E1 Activating Enzyme, being useful in the treatment of cancerSe refiere a un cristal de clorhidrato ((1S,2S,4R)-4-{4-[(1S)-2,3-dihidro-1H-inden-1-ilamino]-7H-pirrolo[2,3-D]pirimidin-7-il}-2-hidroxiciclopentil)metilsulfamato de formula I caracterizado por un patron XRPD que tiene picos de angulos 2(theta): 7.3º, 9.6º, 13.6º, 14.5º, 14.8º, 16.5º, 17.0º, 17.3º, 18.0º, 19.1º, 20.1º, 21.1º, 21.7º, 23.7º ± 0.2 grados. Tambien se refiere a un metodo de obtencion y a una formulacion farmaceutica. Dicho cristal es un inhibidor de enzima activante de E1, siendo util en el tratamiento del cancer
