SAL DE ACIDO TOLUENSULFONICO (TOSILATO) DE N-[3-[(4AR,7AS)-2-AMINO-6-(5-FLUOROPIRIMIDINA-2-IL)-4,4A,5,7-TETRAHIDROPIRROLO[3,4-D][1,3]TIAZINA-7A-IL]-4-FLUORO-FENIL]-5-METOXI-PIRAZINA-2-CARBOXAMIDA
Refers to the Crystalline form of the tosylate Salt of N - [3 - [(4aR, 7aS) - 2 - amino - 4 - (5 - fluoropirimidin - 2 - il) - 4,4a 5.7 - tetrahidropirrolo [3,4-d] [1,3] thiazine - 7a - yl] - 4 - fluoro - 5 - methoxy phenyl] pyrazine-2-carboxamide formula I, characterized in that it comprises, in the Spectrum of x-ray diffraction or N diffraction Angle 2 Theta Peaks, such as: 5.0\u00b0, 19.6\u00b0, 13.8\u00b0 and 18.5\u00b0 (0.2\u00b0 (2 Theta).It also relates to a Pharmaceutical composition. These compounds are useful in the treatment of Alzheimers disease and disorders that involve the Peptide Amyloid beta.Se refiere a la forma cristalina de la sal de tosilato de N-[3-[(4aR,7aS)-2-amino-6-(5-fluoropirimidin-2-il)-4,4a,5,7-tetrahidropirrolo[3,4-d][1,3]tiazina-7a-il]-4-fluoro-fenil]-5-metoxi-pirazina-2-carboxamida de formula I, caracterizado porque comprende, en el espectro de difraccion de rayos X a un angulo de difraccion 2-theta, picos tales como: 5.0°, 19.6°, 13.8° y 18.5° ± 0.2° (2-theta). Tambien se refiere a una composicion farmaceutica. Dichos compuestos son utiles en el tratamiento del Alzheimer y trastornos que implican el peptido beta amiloide.
