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N - [3 - [(4ar, 7a) - 2-amino-6 - (5-fluoroacrylonitrile-2-il) - 4, 4a, 5, 7-tetrahydropyridine [3, 4-d] [1, 3] thiocyano-7a-il] - 4-fluoro-phenyl] - 5-methoxy-pyridine-2-carbohydramine
专利权人:
ELI LILLY AND COMPANY
发明人:
COATES, David Andrew,WOLFANGEL, Craig Daniel
申请号:
PE2017001211
公开号:
PE20171333A1
申请日:
2016.01.22
申请国别(地区):
PE
年份:
2017
代理人:
摘要:
It refers to N - [3 - [(4ar, 7a) - 2-amino-6 - (5-fluoropyrimidin-2-il) - 4, 4a, 5, 7-tetrahydropillo [3, 4-d] [1, 3] tiazina-7a-il] - 4-fluoro-fenil] - 5-methoxi-pirazina-2-carboxamida de form, which is characterized by the analysis of two different types of homologies from different perspectives: 5 degreesPage: 113.8 ° and 18.5 ± 0.2 ° (2-theta). He also mentioned a pharmaceutical composer These compounds can be used in the treatment of Alzheimer's disease and diseases related to cucumbers with beta amide.Se refiere a la forma cristalina de la sal de tosilato de N-[3-[(4aR,7aS)-2-amino-6-(5-fluoropirimidin-2-il)-4,4a,5,7-tetrahidropirrolo[3,4-d][1,3]tiazina-7a-il]-4-fluoro-fenil]-5-metoxi-pirazina-2-carboxamida de formula I, caracterizado porque comprende, en el espectro de difraccion de rayos X a un angulo de difraccion 2-theta, picos tales como: 5.0°, 19.6°, 13.8° y 18.5° ± 0.2° (2-theta). Tambien se refiere a una composicion farmaceutica. Dichos compuestos son utiles en el tratamiento del Alzheimer y trastornos que implican el peptido beta amiloide.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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