ZACHARIE BOULOS,PENNEY CHRISTOPHER,ABBOTT SHAUN,GAGNON LYNE,GROUIX BRIGITTE,LAURIN PIERRE,BIENVENU JEAN FRANCOIS
申请号:
ZA201303032
公开号:
ZA201303032B
申请日:
2013.04.25
申请国别(地区):
ZA
年份:
2014
代理人:
摘要:
Phenylketone carboxylate compounds of Formula I, wherein n=2-6; R=C(0); -OC(O)- or -CH(OH)-; A is (CH2)mCOOH, W(CH2)mCOOH or YCH(COOH)((CH2)pCH3) when B is Ft B is (CH2)mCOOH, W(CH2)mCOOH or YCH(COOH)((CH2)pCH3) when A is Ft or A and B form a 5-7 membered cycloalkyl substituted with COOFt W=0, S or NFt Y=0,S,NH or CH2; m=0-2; p=1-7; have been prepared. These compounds and their pharmaceutically acceptable salts have beneficial therapeutic effects to prevent or treat a condition related to (l) blood disorders, (ii) inflammation related diseases, (iii) renal disorders and/or renal disorders complications, or (iv) fibrosis-related organ dysfunction.