PHENYLKETONE CARBOXYLATE COMPOUNDS AND PHARMACEUTICAL USES THEREOF

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专利权人:

发明人:

申请号：

HK14101763.7

公开号：

HK1188773A

申请日:

2014.02.24

申请国别(地区):

HK

年份:

2014

代理人:

摘要：

Phenylketone carboxylate compounds of Formula I, wherein n=2-6 R=C(0) -OC(O)- or -CH(OH)- A is (CH2)mCOOH, W(CH2)mCOOH or YCH(COOH)((CH2)pCH3) when B is Ft B is (CH2)mCOOH, W(CH2)mCOOH or YCH(COOH)((CH2)pCH3) when A is Ft or A and B form a 5-7 membered cycloalkyl substituted with COOFt W=0, S or NFt Y=0,S,NH or CH2 m=0-2 p=1-7 have been prepared. These compounds and their pharmaceutically acceptable salts have beneficial therapeutic effects to prevent or treat a condition related to (l) blood disorders, (ii) inflammation related diseases, (iii) renal disorders and/or renal disorders complications, or (iv) fibrosis-related organ dysfunction.

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