CHRISTOPHER PENNEY,BRIGITTE GROUIX,LYNE GAGNON,BOULOS ZACHARIE,SHAUN ABBOTT,PIERRE LAURIN,JEAN-FRANCOIS BIENVENU
申请号:
PT11835381
公开号:
PT2632885T
申请日:
2011.10.26
申请国别(地区):
PT
年份:
2018
代理人:
摘要:
Phenylketone carboxylate compounds of Formula I, wherein n=2-6 R=C(0) -OC(O)- or -CH(OH)- A is (CH2)mCOOH, W(CH2)mCOOH or YCH(COOH)((CH2)pCH3) when B is Ft B is (CH2)mCOOH, W(CH2)mCOOH or YCH(COOH)((CH2)pCH3) when A is Ft or A and B form a 5-7 membered cycloalkyl substituted with COOFt W=0, S or NFt Y=0,S,NH or CH2 m=0-2 p=1-7 have been prepared. These compounds and their pharmaceutically acceptable salts have beneficial therapeutic effects to prevent or treat a condition related to (l) blood disorders, (ii) inflammation related diseases, (iii) renal disorders and/or renal disorders complications, or (iv) fibrosis-related organ dysfunction.