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Phenylketone carboxylate compounds and pharmaceutical uses thereof
专利权人:
Shaun Abbott;Lyne Gagnon;Jean-François Bienvenu;Christopher Penney;Pierre Laurin;Boulos Zacharie;Brigitte Grouix
发明人:
Boulos Zacharie,Christopher Penney,Shaun Abbott,Lyne Gagnon,Brigitte Grouix,Pierre Laurin,Jean-François Bienvenu
申请号:
US13882363
公开号:
US09475750B2
申请日:
2011.10.26
申请国别(地区):
US
年份:
2016
代理人:
摘要:
Phenylketone carboxylate compounds of Formula I, wherein n=2-6; R═C(0); —OC(O)— or —CH(OH)—; A is (CH2)mCOOH, W(CH2)mCOOH or YCH(COOH)((CH2)pCH3) when B is Ft B is (CH2)mCOOH, W(CH2)mCOOH or YCH(COOH)((CH2)pCH3) when A is Ft or A and B form a 5-7 membered cycloalkyl substituted with COOFt W=0, S or NFt Y=0,S,NH or CH2; m=0-2; p=1-7; have been prepared. These compounds and their pharmaceutically acceptable salts have beneficial therapeutic effects to prevent or treat a condition related to (l) blood disorders, (ii) inflammation related diseases, (iii) renal disorders and/or renal disorders complications, or (iv) fibrosis-related organ dysfunction.
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