MACKEL, MICHAEL, JOHN,PARK, JOHN, Y.,KARAGEOZIAN, HAMPAR, L.,KARAGEOZIAN, VICKEN, H.
申请号：
EP12782195
公开号：
EP2707036A4
申请日:
2012.05.09
申请国别(地区):
EP
年份:
2015
代理人:
摘要：
Compounds comprising R-G-Cysteic Acid (i.e., R-G-NH-CH(CH 2 -SO 3 H)COOH or Arg-Gly-NH-CH(CH 2 -SO 3 H)COOH) and derivatives thereof, including pharmaceutically acceptable salts, hydrates, stereoisomers, multimers, cyclic forms, linear forms, drug-conjugates, pro-drugs and their derivatives. Also disclosed are methods for making and using such compounds including methods for inhibiting integrins including but not necessarily limited to ± 5 ² 1 -Integrin, ± v ² 3 -Integrin and ± v ² 5 -Integrin, inhibiting cellular adhesion to RGD binding sites, preventing or treating viral or other microbial infections, inhibiting angiogenesis in tumors, retinal tissue or other tissues or delivering other diagnostic or therapeutic agents to RGD binding sites in human or animal subjects.
