HONG-YU LI,HAROLD BURNS BROOKS,JOYCE Z. CRICH,JAMES ROBERT HENRY,MELISSA KATE SLATER,YAN WANG
申请号：
BRPI0721045
公开号：
BRPI0721045A2
申请日:
2007.12.11
申请国别(地区):
BR
年份:
2014
代理人:
摘要：
The present invention provides novel imidazolidinonyl aminopyrimidine compounds believed to have clinical use for treatment of cancer through inhibiting Plk1. wherein: R1 hydrogen, hydroxy, halo, methyl, C1-C2 alkoxy, amino, or methylamino； R2 is hydrogen, halo, or cyano； R3 is hydrogen or halo； R4 is hydrogen, halo, or methyl； provided that at least two of R1, R2, R3, and R4 are hydrogen； R5 is hydrogen, halo, or methyl； or a pharmaceutically acceptable salt thereof.
