Sawyer, Jason Scott,Brooks, Harold Burns,Li, Hong-Yu,Wang, Yan,Henry, James Robert,Crich, Joyce Z.
申请号：
AU2007334040
公开号：
AU2007334040B2
申请日:
2007.12.11
申请国别(地区):
AU
年份:
2012
代理人:
摘要：
The present invention provides novel imidazolidinonyl aminopyrimidine compoundsbelieved to have clinical use for treatment of cancer through inhibiting Plk1.Formula I wherein: R is aminomethyl, (C-Calkyl)aminomethyl, di(C-C alkyl)aminomethyl, N- ethyl-N-methyl-aminomethyl,1-aminoethyl, 1-((C-Calkyl)amino)-ethyl, 3,3,3-trifluoropropylaminomethyl, ethynyl, 2-hydroxy-ethoxy, 2-hydroxyethylaminomethyl,2- cyanoethylaminomethyl, mopholin-4-ylmethyl, methoxymethoxymethyl,cyclopropyl, 1- azetidinylmethyl, 1-pyrrolidinylmethyl, or 1,3-dioxolan-2-yl；R is hydrogen or halo； R is hydrogen or halo； provided thatat least one of R and R is hydrogen； R is hydrogen,methyl, or halo； and is a single bond that is either present or absent, or a pharmaceuticallyacceptable salt thereof.
