STORCK, PIERRE-HENRI,SCHOENTJES, BRUNO,PIETTRE, ARNAUD MARCEL PIERRE,ERMERT, PHILIPP,PONCELET, VIRGINIE SOPHIE,CSOKA, IMRE CHRISTIAN FRANCIS
申请号：
ES08804483
公开号：
ES2382701T3
申请日:
2008.09.19
申请国别(地区):
ES
年份:
2012
代理人:
摘要：
A compound of formula (I): ** Formula ** including any stereochemically isomeric form thereof, in which n is 2, and in which: R1 in each carbon of the group - (CHR1) n- is each selected from independently of hydrogen, halo, hydroxy, amino, mono- or di (C1-6 alkyl) amino, C1-6 alkyl, aryl, heteroaryl, C3-7 cycloalkyl, C1-6 arylalkyl, C1-6 heteroarylalkyl and C3- cycloalkyl 7-C 1-6 alkyl, any one of those mono- or di (C 1-6 alkyl) amino, C 1-6 alkyl, aryl, heteroaryl, C 3-7 cycloalkyl, C 1-6 arylalkyl, heteroaryl-C 1-6 alkyl or C 3-7 cycloalkyl-1-6 alkyl optionally and independently substituted with one or more, preferably one or two, substituents selected from hydroxy, amino, aryl and heteroaryl； s is 0 and then a direct link is understood； t is 0 and a direct link is then understood； R2 is selected from: hydrogen, halo, cyano, amino； C1-6 polyhaloalkyl； C 1-6 alkyl, C 3-7 cycloalkyl, C 2-6 alkenyl, aryl, heteroaryl, C 1-6 arylalkyl, heteroaryl C 1-6 alkyl, C 3-7 cycloalkyl- C 1-6 alkyl, morpholinyl, piperidinyl, pyrrolidinyl, piperazinyl, alkyloxy C 1-6, aryloxy, heteroaryloxy, C 1-6 alkylthio arylthio, heteroarylthio, C 1-6 alkylcarbonyl, C 3-7 carbonylcycloalkyl, heteroarylcarbonyl, C 1-6 alkyloxycarbonyl, C 3-7 carbonyl cycloalkyloxy, aryloxycarbonyl, heteroaryloxycarbonyl, C 1-6 alkylcarbonyloxy, C 3-7 cycloalkylcarbonyloxy, arylcarbonyloxy, heteroarylcarbonyloxy, mono- or di (C 1-6 alkyl) amino, C 1-6 alkylcarbonylamino, C 1-6 alkylcarbonylaminoC 1-6 alkyl , mono- or di (C1-6 alkyl) aminocarbonyl and mono- or di (C1-6 alkyl) aminocarbonylalkyl C1-6, any of said groups being optionally and independently substituted with one or more, preferably one or two, substituents selected from halo, hydroxy, cyano, amino, mono- or di (C1-6 alkyl) amino, C1-6 alkyl, C1- polyhaloalkyl 6, aryl, heteroaryl, C 1-6 alkyloxy, C 1-6 alkylcarbonyl, C 1-6 alkyloxycarbonyl and C 1-6 alkylcarbonyloxy；Un compuesto de fórmula (I): **Fórmula** incluyendo cualquier forma estereoquímicament
