HOBBS, HEATHER,HODGSON, SIMON TEANBY,LACROIX, YANNICK MAURICE,NEEDHAM, DEBORAH,PARR, NIGEL JAMES,PROCOPIOU, PANAYIOTIS ALEXANDROU,RITCHIE, TIMOTHY JOHN,WOODROW, MICHAEL DAVID
申请号：
PE0015572011
公开号：
PE03072012A1
申请日:
2010.02.24
申请国别(地区):
PE
年份:
2012
代理人:
摘要：
Referring to a indazol derivative Compound of formula (i), wherein R1 is a Group - ch2-nh - (c = o) - (formula), a Group - ch2-nh - SO2 - B (formula B) - C (o) nrarb, CH2C (OR) nrarb, between other C1 - C6 is H, alkyl, cycloalkyl C3 - C7, nrarb, among others b is C1 - C6 alkyl ra and RB are H or c1-c6 alkyl R2 is Halogen, alkyl of C1 - C6, CF3, Hydroxy or alkoxy C1 - C6 R3 is Halogen, CF3, hydroxylCH2OH c1-c6 alkoxy, or CHF2 R4 is H, alkyl or Halogen, C1 - C6 Cf3 R5 and R6 are H or c1-c6 alkyl, halogen n is 0 OR 1.Preferred compounds are: N - [(3 - [3 - [({{5-chloro-2 - thienyl) sulfonyl] amino} - 4 - (metiloxi) - 1H - indazol - triazin-1-yl] methyl] phenyl) methyl] acetamide, N - (3 - [3 - [[{{(5-chloro-2 - thienyl) sulfonyl] amino} - 4 - (metiloxi) - 1H - indazol - triazin-1-yl] methyl] phenyl) methyl] - 2 - hydroxy - 2 - metilpropanamida, N - [(3 - [3 - [({{5-chloro-2 - thienyl) sulfonyl] Amin Or} - 4 - (metiloxi) - 1H - indazol - triazin-1-yl] methyl) phenyl) methyl] - 3 - morfolincarboxamida, among others.It also relates to a Pharmaceutical Composition and a preparation method. These compounds are receptor ccr4 antagonists and are useful in the treatment of rhinitis, Asthma, COPD, pulmonary fibrosis, among othersREFERIDA A UN COMPUESTO DERIVADO DE INDAZOL DE FORMULA (I), DONDE R1 ES UN GRUPO -CH2-NH-(C=O)-A (FORMULA a), UN GRUPO -CH2-NH-SO2-B (FORMULA b), -C(O)NRaRb, CH2C(O)NRaRb, ENTRE OTROS A ES H, ALQUILO C1-C6, CICLOALQUILO C3-C7, NRaRb, ENTRE OTROS B ES ALQUILO C1-C6 Ra Y Rb SON H O ALQUILO C1-C6 R2 ES HALOGENO, ALQUILO C1-C6, CF3, HIDROXI O ALCOXI C1-C6 R3 ES HALOGENO, CF3, HIDROXILO, ALCOXI C1-C6, CH2OH O CHF2 R4 ES H, HALOGENO, ALQUILO C1-C6 O CF3 R5 Y R6 SON H, HALOGENO O ALQUILO C1-C6 n ES 0 O 1. SON COMPUESTOS PREFERIDOS: N-[(3-{[3-{[(5-CLORO-2-TIENIL)SULFONIL]AMINO}-4-(METILOXI)-1H-INDAZOL-1-IL] METIL}FENIL)METIL]ACETAMIDA, N-[(3-{[3-{[(5-CLORO-2-TIENIL)SULFONIL]AMINO}-4-(METILOXI)-1H-INDAZOL-1-IL]METIL}FENIL)METIL]-2-HIDROXI-2-METILPROPANAMIDA, N-[
