Referring to tienopirimidina Derivatives of formula I, where R1 is - C (= o) n (R3) (R4) 2a and R2B are R2c is H or h Halogen R2D is H, halogen, among others. C6alquilo R3 is C1, C1 - C6 alkoxy, among others R4 is C1 - c4alquilo, among others.Preferred compounds are: (7S) - 4 - (1H - indazol - 5 - ilamino) - n, n-dimethyl - 5,6,7,8-tetrahydro [1] benzotieno [2,3-d] pyrimidine 7 - carboxamide azetidin IL - 1 - [(7S) - 4 - (1H - indazol - 5 - ilamino) - 5,6,7,8-tetrahydro [1] benzotieno [2,3-d] pyrimidine 7 - il] methanone, among others. These compounds inhibit mknk1 and mknk2, being useful in the treatment of disorders hiperproliferativos and \/ or angiogenesis.Referida a derivados de tienopirimidina de formula I, donde: R1 es –C(=O)N(R3)(R4) R2a y R2b son H R2c es H o halogeno R2d es H, halogeno, entre otros. R3 es C1-C6alquilo, C1-C6 alcoxi, entre otros R4 es C1-C4alquilo, entre otros. Son compuestos preferidos: (7S)-4-(1H-indazol-5-ilamino)-N,N-dimetil-5,6,7,8-tetrahidro[1]benzotieno[2,3-d]pirimidin-7-carboxamida azetidin-1-il[(7S)-4-(1H-indazol-5-ilamino)-5,6,7,8-tetrahidro[1]benzotieno[2,3-d]pirimidin-7-il]metanona, entre otros. dichos compuestos inhiben MKNK1 Y MKNK2, siendo utiles en el tratamiento de trastornos hiperproliferativos y/o angiogenesis.
