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COMPOSITION AND METHOD FOR PREPARING STABLE UNILAMELLAR LIPOSOMAL SUSPENSION
专利权人:
ACCESS BUSINESS GROUP INTERNATIONAL LLC
发明人:
ANDERSON, PENELOPE M.,安德森 佩那罗普M,安德森 佩那羅普M
申请号:
TW098133149
公开号:
TWI537009B
申请日:
2009.09.30
申请国别(地区):
TW
年份:
2016
代理人:
摘要:
Compositions and methods for producing and using stable transparent to translucent unilamellar liposomal suspensions are described. The suspensions include a liposome preparation having a uniform plurality of unilamellar liposomal particles with a mean particle size between about 50 nm to about 290 nm. The particles are suspended in an external phase composition that has a density between about 0.95 g/cc and about 1.25 g/cc, and that is present in an amount between about 30% to 75% of the weight of the liposomal suspension. The liposome preparation is formed from an aqueous liposomal solution that includes an oil-soluble composition and a water-soluble composition. The oil-soluble composition is present at a concentration between about 5% to about 33% by weight of the liposomal solution and the water-soluble composition is present at a concentration between about 67% to about 95% by weight of the liposomal solution.本發明描述用於製造以及使用穩定的透明至半透明單層脂質體懸浮液的組成物以及方法。該等懸浮液包括一具有均勻的複數單層脂質體粒子的脂質體製劑,該等單層脂質體粒子具有一介於大約50nm至大約290nm之間的平均粒徑。該等粒子被懸浮在一外相組成物中,該外相組成物具有一密度是介於大約0.95g/cc與大約1.25g/cc之間,並且呈一介於該脂質體懸浮液的重量的大約30%至大約75%之間的數量而存在。該脂質體製劑是由一包括一油溶性組成物以及一水溶性組成物的水性脂質體溶液所形成。該油溶性組成物呈一介於大約5%至大約33%(以該脂質體溶液的重量計)之間的濃度而存在,而該水溶性組成物呈一介於大約67%至大約95%(以該脂質體溶液的重量計)之間的濃度而存在。
来源网站:
中国工程科技知识中心
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