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Composition and method for preparing stable unilamellar liposomal suspension
专利权人:
Penelope M. Anderson
发明人:
Penelope M. Anderson
申请号:
US12245528
公开号:
US09445975B2
申请日:
2008.10.03
申请国别(地区):
US
年份:
2016
代理人:
摘要:
Compositions and methods for producing and using stable transparent to translucent unilamellar liposomal suspensions are described. The suspensions include a liposome preparation having a uniform plurality of unilamellar liposomal particles with a mean particle size between about 50 nm to about 290 nm. The particles are suspended in an external phase composition that has a density between about 0.95 g/cc and about 1.25 g/cc, and that is present in an amount between about 30% to about 75% of the weight of the liposomal suspension. The liposome preparation is formed from an aqueous liposomal solution that includes an oil-soluble composition and a water-soluble composition. The oil-soluble composition is present at a concentration between about 5% to about 33% by weight of the liposomal solution and the water-soluble composition is present at a concentration between about 67% to about 95% by weight of the liposomal solution.
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