1. The compound of formula 1 or its pharmaceutically acceptable salts, where a represents a group of formula (a)； (b)； (c) or (d) B represents a group of formula (e)； (f)； (g) or (h) C represents a group of formula (i)； (j)； (k) or (m) m represents 0 or 1； n is in the range from 0 to 3； p is in the range from 0 to 2； q is in the range from 0 to 3； r is in the range from 0 to 3； s is in the range from 0 to 2； t is 0 or 1； u is in the range from 0 to 3； R is hydrogen or C1-6 alkyl； R is hydrogen or C1-6 alkyl； R is C1-6 alkyl； Cycloalkyl； Cycloalkyl-alkyl； heterocyclyl； heterocyclyl-C1-6alkyl； phenyl-C1-6alkyl or C1-6alkylsulfonyl, where each of the C1-6alkyl, Cycloalkyl, Cycloalkyl-C1-6alkyl and phenyl-C1-6alkyl groups may independently be substituted one or more times by a halogen atom； R4 represents hydrogen or C1-6alkyl； R4 represents hydrogen or C1-6alkyl； R4 represents cyano； - (CH) -NRR； - (CH) -S (O) -R； - (CH) -C (O) -NRR ；-( CH) -S (O) -NRR； - (CH) -NR-C (O) -R； - (CH) -NR-C (O) -NRR or - (CH) -NR-S (O) -R, where v is 0 or 1, w is in the range from 0 to 2； each of the R and R groups independently represents represents hydrogen or C1-6alkyl； R1 represents C1-6alkyl； Cycloalkyl or cycloalkyl-alkyl； and R 1 is hydrogen or C 1-6 alkyl； each R group independently represents C 1-6 alkyl； halo； Alkoxy； cyano； haloalkyl； hydroxy-C1-6alkyl； halo-alkoxy or C1-6alkylsulfonyl； R1 is C1-6alkyl； Cycloalkyl or Cycloalkyl-C1-6alkyl； R4 represents hydrogen or C1-6alkyl； R4 represents hydrogen or C1-6alkyl； R4 represents hydrogen； hydroxy； cyano； - (CH) -NRR； - (CH) -S (O) -R； - (CH) -C (O) -NRR； - (CH) -S (O) -NRR； - (CH) -NR-C (O) -R； - (CH) -NR-C (O) -NRR or - (CH) -NR-S (O) -R； each R group is independently C 1-6 alkyl； halo； Alkoxy； cyano； haloalkyl； halo-alkoxy or C1-6alkylsulfonyl； each R group is independently C1-6alkyl； halo； Alkoxy； cyano； ha1. Соединение формулы 1или его фармацевтически приемлемые соли,где А представляет собой группу формулы (а)； (b)； (с) или (d)В
