KANNAN, GUNASEKARAN,LAVALLEE, JENNIFER,JACOBSEN, FREDERICK W.
申请号：
CA2919076
公开号：
CA2919076A1
申请日:
2014.07.30
申请国别(地区):
CA
年份:
2015
代理人:
摘要：
This disclosure provides polypeptides comprising an antibody Fc region having a deletion of one or more cysteine residues in the hinge region and substitution with a sulfhydryl-containing residue of one or more CH3-inteface amino acids. Also, provided are Fc-fusion proteins and antibodies containing said polypeptides, nucleic acids and vectors encoding said polypeptides, along with host cells and methods for making said polypeptides.
