KANNAN, Gunasekaran,LAVALLEE, Jennifer,JACOBSEN, Frederick W
申请号：
HK16112553.6
公开号：
HK1224203A
申请日:
2016.11.01
申请国别(地区):
HK
年份:
2017
代理人:
摘要：
This disclosure provides polypeptides comprising an antibody Fc region having a deletion of one or more cysteine residues in the hinge region and substitution with a sulfhydryl-containing residue of one or more CH3-interface amino acids. Also, provided are Fc-fusion proteins and antibodies containing said polypeptides, nucleic acids and vectors encoding said polypeptides, along with host cells and methods for making said polypeptides.
