Gunasekaran KANNAN,Jennifer LAVALLEE,Frederick W. JACOBSEN
申请号：
US14909431
公开号：
US20160193295A1
申请日:
2014.07.30
申请国别(地区):
US
年份:
2016
代理人:
摘要：
This disclosure provides polypeptides comprising an antibody Fc region having a deletion of one or more cysteine residues in the hinge region and substitution with a sulfhydryl-containing residue of one or more CH3-interface amino acids. Also, provided are Fc-fusion proteins and antibodies containing said polypeptides, nucleic acids and vectors encoding said polypeptides, along with host cells and methods for making said polypeptides.
