Chris Van Haesendonck;Johan Snauwaert;Maarten Gysemans
发明人:
Maarten Gysemans,Johan Snauwaert,Chris Van Haesendonck
申请号：
US13808859
公开号：
US20130115257A1
申请日:
2011.07.08
申请国别(地区):
US
年份:
2013
代理人:
摘要：
Methods and compositions for treating biofilms and diseases associated with amyloidosis such as Alzheimer's, Parkinson's and Huntington's disease, and Type 2 diabetes, by destroying amyloid fibrils in a two-step treatment are disclosed. The first step consists of binding to the amyloid fibril an intercalating molecule with a negatively charged group such as Congo red. The second step consists of adding metal ions, such as silver, gold(I), copper(I), palladium or lead ions or metal colloids of silver or gold, which destabilize the amyloid-dye complex. This process results in a disintegration of the fibril into peptide monomers and small aggregates of monomers.
