Merck Sharp & Dohme Corp.;Acumen Pharmaceuticals; Inc.;Acumen Pharmaceuticals, Inc.
发明人:
Goure, William F,Hefti, Franz F.,Gaspar, Renee C.,Shughrue, Paul J.,Wang, Fubao,Wang, Weirong,Zhang, Ningyan,Zhao, Wei-Qin
申请号：
AU2013355359
公开号：
AU2013355359A1
申请日:
2013.12.04
申请国别(地区):
AU
年份:
2015
代理人:
摘要：
This invention is a method and kit for treating a disease associated with, or resulting from, the accumulation of soluble oligomer amyloid beta 1-42 using an antibody, or antibody fragment thereof, that has a higher affinity for amyloid beta 1-42 oligomers than for amyloid beta 1-42 monomer, amyloid beta 1-40 monomer, plaques and amyloid beta fibrils, wherein the antibody is in combination with a tau therapeutic or an inhibitor of amyloid beta production or aggregation.
