The invention relates to nitric oxide releasing phosphodiesterase type 5 (PDE5) inhibitors of formula (I) or (Ib) or (II) or a stereoisomer or a pharmaceutically acceptable salt thereof:useful for the treatment of ocular condition associated with elevated intraocular pressure such as ocular hypertension, glaucoma or retinopathies. The invention further relates to 3-[(2S)-2,3-bis(nitrooxy)propoxy]propanoic acid and 6-(nitrooxy)hexanoic acid for use in the treatment of ocular condition associated with elevated intraocular pressure such as ocular hypertension, glaucoma or retinopathies.本發明係關於式(I)或(Ib)或(II)之一氧化氮釋放第5型磷酸二酯酶(PDE5)抑制劑或其立體異構體或醫藥學上可接受之鹽:其有用於治療與眼內壓升高相關的眼病症諸如高眼壓、青光眼或視網膜病變。本發明進一步係關於3-[(2S)-2,3-雙(硝氧基)丙氧基]丙酸及6-(硝氧基)己酸,其用於治療與眼內壓升高相關的眼病症諸如高眼壓、青光眼或視網膜病變。