The present invention relates to a medicine capable of being continuously administered for a long period for treating or preventing glaucoma or ocular hypertension, which has stable intraocular pressure lowering effect that is not decreased due to the long-term administration.The present invention relates to a therapeutic agent containing a Rho kinase inhibitor for glaucoma or ocular hypertension for long-term and continuous administration. More specifically, the present invention relates to therapeutic agent containing Rho kinase inhibitor for treating glaucoma or ocular hypertension of a patient who has been administrated with a therapeutic agent for glaucoma or ocular hypertension containing Rho kinase inhibitor for a certain period but requiring a further enhanced intraocular pressure lowering effect.本發明係關於一種用以預防或治療青光眼或是高眼壓症之可長期連續投予的藥劑，其不會因長期投予而減弱作用，能呈現安定的眼壓下降效果。本發明係關於一種含有Rho激酶抑制劑而成之長期連續投予用的青光眼或高眼壓症之治療劑，更詳而言之，係關於一種用以治療患者的青光眼或高眼壓症之含有該Rho激酶抑制劑而成之治療劑，前述患者係經一定期間連續投予含有Rho激酶抑制劑而成之青光眼或高眼壓症之治療劑的患者，且為需要更為增強的眼壓下降作用的青光眼或高眼壓症之患者。
