Extended its duration and intraocular pressure lowering effect is powerful, the provision of a preventive or therapeutic agent for ocular hypertension or glaucoma prevention. Therapeutic agents or preventive glaucoma comprising a combination of a Rho kinase inhibitor and α 1-blockers.眼圧下降作用が強力で且つその持続時間が延長された、緑内障予防若しくは高眼圧症の予防又は治療剤の提供。Rhoキナーゼ阻害剤とα1遮断薬とを組み合わせてなる緑内障予防又は治療剤。