The purpose of the present invention is to identify a combination of drugs for the prevention or treatment of glaucoma or ocular hypertension, said combination being useful as a prophylactic or therapeutic agent for glaucoma or ocular hypertension. Combining sepetaprost and an Rho-kinase inhibitor enhances the intraocular pressure-lowering effect in comparison to when either drug is used alone. The drugs may be administered concurrently or as a combination drug.本發明之目的在於發現作為青光眼或高眼壓症之預防或治療劑有用之青光眼或高眼壓症之預防或治療藥之組合。本發明藉由將賽佩普斯特與Rho激酶抑制劑加以組合，與單獨使用各藥劑時相比，眼壓下降作用增強。作為投予之形態，可併用投予，亦可以調配劑之形式投予。
