PROBLEM TO BE SOLVED: To provide a drug therapy for preventing glaucoma or for preventing or treating ocular hypertension, where the action of lowering intraocular pressure is strong and its duration is extended.SOLUTION: The present invention provides a combination of 3,4-dihydro-8-(2-hydroxy-3-isopropylamino)propoxy-3-nitroxy-2H-1-benzopyran or a salt thereof or their solvates and α2 stimulant for the prevention or treatment of glaucoma.SELECTED DRAWING: NoneCOPYRIGHT: (C)2016,JPO&INPIT【課題】眼圧下降作用が強力且つその持続時間が延長された、緑内障予防若しくは高眼圧症の予防又は治療するための薬物療法の提供。【解決手段】緑内障予防又は治療のための、3,4-ジヒドロ-8-(2-ヒドロキシ-3-イソプロピルアミノ)プロポキシ-3-ニトロキシ-2H-1-ベンゾピラン若しくはその塩又はそれらの溶媒和物とα2刺激薬との組み合わせ。【選択図】なし