The purpose of the present invention was to discover a combination of drugs for the prevention or treatment of glaucoma or ocular hypertension that would be useful as an agent for the prevention or treatment of glaucoma or ocular hypertension. Combining omidenepag with ripasudil or netarsudil results in mutual complementation and/or reinforcement of intraocular pressure reduction activity. Administration may be by combined administration or as a compound agent.本發明之目的在於發現作為青光眼或高眼壓症之預防或治療劑有用之青光眼或高眼壓症之預防或治療藥之組合。本發明藉由將歐米德尼培與雷帕地爾或奈他地爾加以組合，而互相補充及/或增強眼壓下降作用。作為投予之形態，可併用投予，亦可以調配劑之形式投予。
