The purpose of the present invention was to discover a combination of drugs for the prevention or treatment of glaucoma or ocular hypertension that would be useful as an agent for the prevention or treatment of glaucoma or ocular hypertension. Combining omidenepag with ripasudil or netarsudil results in mutual complementation and/or reinforcement of intraocular pressure reduction activity. Administration may be by combined administration or as a compound agent.
