PSMA及CD3雙特異性T細胞嚙合抗體構築體农业专利-农业学术服务平台

发明人:: RAUM, TOBIAS,瑞乌　托拜尔斯,瑞烏　托拜爾斯,MUENZ, MARKUS,蒙兹　马克斯,蒙茲　馬克斯,BROZY, JOHANNES,波西　乔汉斯,波西　喬漢斯,KUFER, PETER,库佛　彼德,庫佛　彼德,HOFFMANN, PATRICK,霍夫曼　派翠克,FRIEDRICH, MATTHIAS,弗瑞德里奇　马修斯,弗瑞德里奇　馬修斯,RATTEL, BENNO,瑞乌托拜尔斯,瑞烏托拜爾斯,蒙兹马克斯,蒙茲馬克斯,波西乔汉斯,波西喬漢斯,库佛彼德,庫佛彼德,霍夫曼派翠克,弗瑞德里奇马修斯,弗瑞德里奇馬修斯

摘要：: The present invention provides bispecific antibody constructs of a specific Fc modality characterized by comprising a first domain binding to PSMA, a second domain binding to an extracellular epitope of the human and the Macaca CD3ε chain and a third domain, which is the specific Fc modality. Moreover, the invention provides a polynucleotide, encoding the antibody construct, a vector comprising this polynucleotide, host cells, expressing the construct and a pharmaceutical composition comprising the same.本發明提供具有特異性Fc模態(modality)之雙特異性抗體構築體，其特徵為包含結合至PSMA之第一域、結合至人類及獼猴(Macaca)CD3ε鏈之細胞外抗原決定基之第二域、以及為該特異性Fc模態之第三域。另外，本發明提供編碼該抗體構築體之聚核苷酸、包含該聚核苷酸之載體、表現該構築體之宿主細胞及包含其之醫藥組合物。