針對MUC17和CD3之雙特異性抗體構建體农业专利-农业学术服务平台

发明人:: ARVEDSON, TARA,亚维德森　泰拉,亞維德森　泰拉,RAUM, TOBIAS,瑞乌　托拜耳斯,瑞烏　托拜耳斯,ROSS, SANDRA,萝丝　珊卓,蘿絲　珊卓,DAHLHOFF, CHRISTOPH,戴尔哈福　克里斯多福,戴爾哈福　克里斯多福,CHEN, IRWIN,陈　艾文,陳　艾文,BAILIS, JULIE,贝里斯　茱莉,貝里斯　茱莉,PENDZIALEK, JOCHEN,潘德利尔

摘要：: The present invention provides bispecific antibody constructs characterized by comprising a first domain binding to MUC17, a second domain binding to an extracellular epitope of the human and the Macaca CD3ε chain and optionally a third domain, which is a specific Fc modality. Moreover, the invention provides a polynucleotide, encoding the antibody construct, a vector comprising this polynucleotide, host cells, expressing the construct and a pharmaceutical composition comprising the same.本發明提供了雙特異性抗體構建體，其特徵在於包含與MUC17結合的第一結構域、與人和獼猴CD3ε鏈的細胞外表位結合的第二結構域以及視需要第三結構域，該第三結構域係特異性Fc模式。此外，本發明提供了編碼該抗體構建體的多核苷酸、包含這種多核苷酸的載體、表現該構建體的宿主細胞以及包含該抗體構建體的藥物組成物。