CONSTRUCTIONS D'ANTICORPS BISPECIFIQUES DIRIGES CONTRE MUC17 ET CD3

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专利权人:

AMGEN RESEARCH (MUNICH) GMBH;AMGEN INC.

发明人:

RAUM, TOBIAS,ARVEDSON, TARA,BAILIS, JULIE,DAHLHOFF, CHRISTOPH,ROSS, SANDRA,CHEN, IRWIN,BLUMEL, CLAUDIA,NAHRWOLD, ELISABETH,PENDZIALEK, JOCHEN,WAHI, JOACHIM

申请号：

CA3087151

公开号：

CA3087151A1

申请日:

2018.12.31

申请国别(地区):

CA

年份:

2019

代理人:

摘要：

The present invention provides bispecific antibody constructs characterized by comprising a first domain binding to MUC17, a second domain binding to an extracellular epitope of the human and the Macaca CD3e chain and optionally a third domain, which is a specific Fc modality. Moreover, the invention provides a polynucleotide, encoding the antibody construct, a vector comprising this polynucleotide, host cells, expressing the construct and a pharmaceutical composition comprising the same.

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