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FORMULATIONS D'ETANERCEPT STABILISEES PAR DE LA MEGLUMINE
专利权人:
INC.;COHERUS BIOSCIENCES
发明人:
MANNING, MARK,MURPHY, BRIAN
申请号:
CA2851646
公开号:
CA2851646A1
申请日:
2012.10.18
申请国别(地区):
CA
年份:
2013
代理人:
摘要:
The present invention is an aqueous stabilized formulation of etanercept comprising: etanercept; and stabilizing ingredients to retard instability, aggregation and/or fragmentation of the etanercept in the formulation, said stabilizing ingredients being comprised of at least one of the following: {a) meglumine; or (b) meglumine in combination with sucrose; or {c) meglumine in combination with sodium chloride; or (d) meglumine in combination with sodium chloride and sucrose. Various technical terms used in the following discussion are defined below in the section entitled "Definitions'' and throughout the remainder of the specification. The stabilized etanercept formulations of the present invention elicit long term storage stability.
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中国工程科技知识中心
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