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Etanercept formulations stabilized with meglumine
专利权人:
发明人:
MANNING MARK,MURPHY BRIAN
申请号:
IN2590/CHENP/2014
公开号:
IN2014CN02590A
申请日:
2014.04.04
申请国别(地区):
IN
年份:
2015
代理人:
摘要:
The present invention is an aqueous stabilized formulation of etanercept comprising: etanercept and stabilizing ingredients to retard instability aggregation and/or fragmentation of the etanercept in the formulation said stabilizing ingredients being comprised of at least one of the following: {a) meglumine or (b) meglumine in combination with sucrose or {c) meglumine in combination with sodium chloride or (d) meglumine in combination with sodium chloride and sucrose. Various technical terms used in the following discussion are defined below in the section entitled "Definitions and throughout the remainder of the specification. The stabilized etanercept formulations of the present invention elicit long term storage stability.
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